quality of life after pulmonary embolism

J Clin Epidemiol 1998, 51: 1013–1023. Health-related quality of life (HRQoL) after deep vein thrombosis (DVT) has been extensively studied. Most patients can maintain a good quality of life after treatment. All authors read and approved the final manuscript. Terms and Conditions, Acute venous thromboembolism (VTE), defined as deep vein thrombosis (DVT) and/or pulmonary embolism (PE), is common and has a high impact on morbidity, mortality, and costs of care [1],[2]. 2008;168:425–430. Baseline characteristics were shown as proportions or medians and ranges, as appropriate. -, Pengo V, Lensing AW, Prins MH, Marchiori A, Davidson BL, Tiozzo F, Albanese P, Biasiolo A, Pegoraro C, Iliceto S, Prandoni P, Thromboembolic Pulmonary Hypertension Study Group Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. QualityMetric, Incorporated, Lincoln, Rhode Island; 2001. To estimate the overall impact of PE on quality of life, we developed a PEmb-QoL summary score. Google Scholar, Pengo V, Lensing AW, Prins MH, Marchiori A, Davidson BL, Tiozzo F, Albanese P, Biasiolo A, Pegoraro C, Iliceto S, Prandoni P: Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. Privacy The PEmb-QoL is a validated 40-item questionnaire to quantify health-related quality of life in patients having experienced pulmonary embolism (PE). [8] and might be explained by the fact that these dimensions focus on the extent of limitations when performing work or physical exercises. Two questions (Q2 ‘At what time of day are your lung symptoms most intense?’ and Q3 ‘Compared to one year ago, how would you rate the condition of your lungs in general now?’) were not scored. In case a patient returned an incomplete questionnaire, a study collaborator contacted the patient by telephone to complete all missing items. Besides the transient discomfort related to acute VTE, health-related quality of life is substantially influenced by the development of VTE-related complications [3]. California Privacy Statement, It covers six health dimensions: frequency of complaints, activities of daily living limitations, work-related problems, social limitations, intensity of complaints, and emotional complaints. Abu Bakar N, Torkamani M, Tanprawate S, Lambru G, Matharu M, Jahanshahi M. J Headache Pain. Summary. Internal consistency refers to the extent to which items comprising the score measure the same construct (i.e., homogeneity of the score), and was considered acceptable when Cronbach’s alpha was between 0.7 and 0.95 [14]. Methods The multinational Home Treatment of Pulmonary Embolism (HoT-PE) single-arm management trial investigated early discharge followed by ambulatory treatment with rivaroxaban.  |  The confirmation of PE was based on either a high-probability ventilation-perfusion lung scan or a positive computed tomography scan [12],[13]. The Article  statement and Cite this: Addressing quality-of-life issues after an acute pulmonary embolism - Medscape - Jul 30, 2010. Health Qual Life Outcomes. Thus, the French version of the PEmb-QoL can be used with confidence in prospective studies to assess PE-specific quality of life and symptoms. In a second step, two naïve English speakers performed a backward translation into English. We contacted 33 participants (32%) by phone to complete missing items. Given that patients in our cohort were older (63 vs. 56 years) and less likely to have cardiopulmonary comorbidity (13% vs. 20%) and obesity (13% vs. 39%) than patients in the study by Klok et al. The local ethics committee (Commission cantonale (VD) d’éthique de la recherche sur l’être humain) approved the study and all patients provided written consent. 10.1097/00007632-200012150-00014, CAS  10.1056/NEJMcp0804570, CAS  N Engl J Med. Riva N, Borg Xuereb C, Makris M, Ageno W, Gatt A. Riva N, Borg Xuereb C, Ageno W, Makris M, Gatt A. Psychol Res Behav Manag. J Thromb Haemost 2007, 5(Suppl 1):310–317. Would you like email updates of new search results? volume 12, Article number: 174 (2014) Spine (Phila Pa 1976) 2000, 25: 3186–3191. We also performed an exploratory factor analysis. It covers six health dimensions: frequency of complaints, activities of daily living limitations, work-related problems, social limitations, intensity of complaints, and emotional complaints. The correlation between intensity of complaints and bodily pain was clinically also plausible. [8] showed that items designated to social limitations and intensity of complaints had higher loadings in other dimensions, suggesting that these two dimensions might not be justifiable. Introduction. The SF-36 also provides a physical and mental health summary score. Blood. Overall, 46 patients (45%) were aged ≥65 years, and 39% were women (Table 1). The French version of the PEmb-QoL showed good reliability (internal consistency, item–total and inter-item correlations), reproducibility (test-retest reliability), and validity (convergent, discriminant) in French-speaking patients with PE. 10.1056/NEJMoa032274. MR and MM collected the data. Recently, a Norwegian version of the PEmb-QoL was successfully validated [10]. We successfully validated the French version of the PEmb-QoL questionnaire in patients with PE. French-speaking consecutive adult patients with an acute, objectively confirmed PE admitted to the emergency department of a Swiss university hospital between 08/2009 and 09/2011 were recruited telephonically. To cite this article: Cohn DM, Nelis EA, Busweiler LA, Kaptein AA, Middeldorp S. Quality of life after pulmonary embolism: the development of the PEmb-QoL questionnaire. However, our enrolment rate compared well with previous studies, in which less than 40% of screened patients with VTE underwent quality of life assessments [10],[25]. Most patients can maintain a good quality of life after treatment. item 6 (Interference with normal social activities) in symptoms and items 8 (Intensity of breathlessness) and 9 g-i (Burden to family and friends, Afraid to exert yourself, Limited in taking a trip) in limitations in daily activity. Notably, items 6 (Interference with normal social activities), 8 (Intensity of breathlessness), and 9 g-i (Burden to family and friends, Afraid to exert yourself, Limited in taking a trip) were not taken into account in these three dimensions because these did not contribute significantly to either of them. Although clinical trials have demonstrated short-term benefit of catheter-based therapies to improve right ventricular (RV) dysfunction following acute pulmonary embolism (PE), 1–4 a paucity of data regarding long-term RV remodeling, functional status, and quality of life exists to guide integration of these revascularization strategies into evidence-based clinical practice. Three items were not clearly assignable to a meaningful dimension in the French version of the PEmb-QoL: item 6 (“During the past four weeks, to what extend have your lung symptoms interfered with your normal social activities with family, friends, neighbors, or groups?”), item 8 (“How much breathlessness have you experienced in the past four weeks?”) and item 9 g-i (“How much of the time during the past four weeks (g) did you feel that you were a burden to your family and friends, (h) were you afraid to exert yourself, (i) did you feel limited in taking a trip?”). Objectives: To assess the long-term risk for adverse events after PE.. Methods: Consecutive patients diagnosed with PE between January 2001 and July 2007, and patients in whom PE was ruled out from a previous study were followed until July 2008 for the occurrence of … However, less than a third of patients had to be contacted because they had one or more missing items. Background: While the importance of patients' quality of life (QoL) in heart failure is increasingly been acknowledged and has become a treatment target, the burden of an acute pulmonary embolism (PE) on patient' QoL has received little attention thus far. METHODS The multinational Home Treatment of Pulmonary Embolism (HoT-PE) single-arm management trial investigated early discharge followed by ambulatory treatment with rivaroxaban. J Clin Epidemiol 2006, 59: 1049–1056. PubMed  BACKGROUND Early discharge of patients with acute low-risk pulmonary embolism (PE) requires validation by prospective trials with clinical and quality of life outcomes. We decided that a time period of ten days between the repeated distributions of the questionnaires was long enough to prevent recall bias but short enough to ensure that a clinical change in the symptoms being measured was unlikely to occur. Our hypothesis was that correlation with age, gender, and clinical characteristics would be weak. While items 9 g-i (Burden to family and friends, Afraid to exert yourself, Limited in taking a trip) were expected to cluster in the dimension “emotional complaints”, they clustered in “limitations in daily activity” in our study. doi: 10.1056/NEJMcp0804570. 2018 Jun;166:86-91. doi: 10.1016/j.thromres.2018.04.020. Altman DG: Practical statistics for medical research. PubMed Google Scholar. Our factor analysis supported the formation of three dimensions: limitations in daily activity (items 4b-m, 5a-d), symptoms (items 1a-h and 7), and emotional complaints (items 9a-f and j). Median transformed scores were 9.4 (interquartile range [IQR] 3.1-21.9) for frequency of complaints (FC), 15.4 (IQR 3.8-41.7) for activities of daily living limitations (AL), 0.0 (IQR 0.0-50.0) for work-related problems (WP), 0.0 (IQR 0.0-25.0) for social limitations (SL), 20.0 (IQR 10.0-40.0) for intensity of complaints (IC), 14.0 (IQR 6.0-34.0) for emotional complaints (EC), and 14.7 (IQR 5.9-36.3) for the PEmb-QoL summary score (PEmb). eCollection 2019. Of 242 patients with PE screened, 61 could not be reached, 42 refused to participate, 20 had dementia, 8 lived in a nursing home, 6 were unable to speak French, and 3 lived abroad, leaving a final study sample of 102 patients. METHODS: QoL was assessed in 109 consecutive out-patients with a history of objectively confirmed acute PE (mean age 60.4 ± 15.0 years, 56 females), using the generic Short Form-36 (SF-36) and the disease specific Pulmonary Embolism Quality of Life questionnaire (PEmb-QoL). Methods: more than 15% of patients had the lowest score possible, indicating the best possible quality of life. The effect of acute pulmonary embolism (PE) on patient quality of life (QoL) has been previously studied using both the generic Short Form 36 (SF-36) instrument as well as the more disease-specific pulmonary embolism quality of life (PEmb-QoL) instrument [1, 2].Klok et al. Multivariate Behav Res 1966, 1: 245–276. Because acceptability affects the quality of the data obtained, it was assessed by examining completeness of data and score distribution. Correspondence to Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Bern Open Repository and Information System, Konstantinides S. Acute pulmonary embolism. Conclusion: I. conceptual framework and item selection. The transformed PEmb-QoL dimension scores were depicted in a box plot as medians with interquartile range (IQR). -, Kahn SR, Ginsberg JS. Go to follow-up appointments and take blood thinners as directed. The PREFER in VTE registry, a prospective, observational study conducted in seven European countries, was used. N Engl J Med 2008, 359: 2804–2813. It is dangerous because almost a quarter of pulmonary embolism cases present as sudden death and up to a third of pulmonary embolism will ultimately be fatal. 10.1111/j.1538-7836.2009.03341.x, Klok FA, Cohn DM, Middeldorp S, Scharloo M, Buller HR, van Kralingen KW, Kaptein AA, Huisman MV: Quality of life after pulmonary embolism: validation of the PEmb-QoL Questionnaire. OH, FAK, and DMC critically revised the manuscript. Study. Quality of life after pulmonary embolism as assessed with SF-36 and PEmb-QoL By Josien van Es, Paul L. den Exter, Ad A. Kaptein, Cornelie D. Andela, Petra M. G. Erkens, Frederikus A. Klok, Renee A. Douma, Inge C. M. Mos, Danny M. Cohn, Pieter W. Kamphuisen, Menno V. Huisman and Saskia Middeldorp Thus, the French version of the PEmb-QoL questionnaire met standard criteria of reliability and validity for use as a patient-reported measure of outcome in patients with PE, as previously shown for the Dutch version of the questionnaire. Manage cookies/Do not sell my data we use in the preference centre. We are currently developing a disease-specific questionnaire to measure quality of life after pulmonary embolism (PE). Our study has potential limitations. Klok FA, van KralingenKW, van Dijk AP, et al. The postal questionnaire will contain questions on disease symptoms, comorbidity, health-related quality of life (Pulmonary Embolism Quality of Life Questionnaire,16 EQ-5D,13 anxiety and depression (Hospital anxiety and depression scale14), dyspnoea, major bleeding complications, recurrent events and healthcare utilisation (readmissions, visits to physicians, clinics and emergency departments). Epub 2015 Apr 9. 2016 Dec;17(1):79. doi: 10.1186/s10194-016-0674-1. Quality of life after pulmonary embolism: Prospective validation of the German version of the PEmb-QoL questionnaire. Depending on the underlying cause of the pulmonary embolism, patients remain on anticoagulation medication for several weeks to months after treatment to prevent clots from redeveloping, with periodic checkups for incidence of bleeding. Construct validity refers to the extent to which PEmb-QoL scores relate to other measures in a manner consistent with theoretically derived hypotheses [14]. • Lower QoL in patients after acute PE vs. DVT alone • especially on the subscales physical quality of life and mental fatigue 1. -, Spencer FA, Gore JM, Lessard D, Douketis JD, Emery C, Goldberg RJ. All item-total correlation values were >0.2, ranging from 0.53 to 0.92 (data not shown for individual items). Pulmonary embolism (PE) occurs in 600,000 to 1 million individuals each year, and has a 15% 1-year mortality, making it ... limitation, and impaired quality of life that persist for longer than 3 months after effective anticoagulation for acute PE. The scores vary from 0 to 100 for each dimension, with higher values indicating better health [18],[19]. 3rd edition. Background: Even though quality of life (QoL) has become a key component of medical care, there is no instrument available that specifically measures QoL after pulmonary embolism (PE). Given that the PEmb-QoL questionnaire is the only available validated instrument to assess QoL after PE [8], we aimed to prospectively validate the psychometric properties of a French version of the PEmb-QoL questionnaire (Additional file 1). The six dimensions of the PEmb-QoL were originally defined clinically and not statistically, assuming that these six dimensions would provide unique information to the treating physician [7]. All dimensions had floor effects, ranging from 13% for emotional complaints (Q9) to 66% for social limitations (Q6) (Table 2). Recently, the Pulmonary Embolism Quality of Life (PEmb-QoL) Questionnaire has been developed to address this gap. Criteria for acceptability included <15% floor and ceiling effects for dimensions and summary score [14]. We tested reproducibility by repeating the PEmb-QoL questionnaire after ten days (test-retest reliability). Validating the Chinese version of the PEmb-QoL questionnaire: A measure for quality of life assessment after pulmonary embolism. Disease-specific quality of life questionnaires are necessary to better detect treatment effects and change over time in patients having the same disease. The aim of the current study was to translate and test the psychometrical properties of the disease-specific pulmonary embolism quality-of-life questionnaire (PEmb-QoL). The median (range) time between occurrence of the index PE and study enrollment was 15 (5–23) months. N Engl J Med 2004, 350: 2257–2264. Quality of life after pulmonary embolism: the development of the PEmb-QoL questionnaire. Recently, a large group of patients with persistent dyspnea, poor physical capacity, and reduced health-related quality of life (HRQoL) following pulmonary embolism (P Introduction. We used patient medical records to collect the following baseline characteristics for all enrolled patients: age, gender, cardiopulmonary comorbidity (defined as any cardiac disease with systolic or diastolic ventricular dysfunction or any obstructive or restrictive pulmonary disease), active cancer (defined as cancer with ongoing oncologic or palliative treatment within the previous six months), obesity (defined as body mass index more than 30 kg/m2), history of prior VTE, and the time interval between the index PE and study inclusion. Thromb Res. Finally, we were not able to assess responsiveness of the PEmb-QoL questionnaire, that is, its ability to detect a clinically meaningful change over time [8]. 10.1016/j.jclinepi.2006.03.012. 10.1111/j.1538-7836.2007.02489.x, Article  A pulmonary embolism (PE) is the sudden blockage of a blood vessel in the lungs by an embolus. Background Pulmonary embolism (PE) reduces quality of life (QOL). [8], we could not exclude the possibility that these differences in patient baseline characteristics did not contribute to differences in self-reported health measures. 10.1001/archinte.164.1.17, Spencer FA, Gore JM, Lessard D, Douketis JD, Emery C, Goldberg RJ: Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study. The PEmb-QoL questionnaire contains nine questions (40 items) covering six dimensions: frequency of complaints (Q1, 8 items), activities of daily living limitations (Q4, 13 items), work-related problems (Q5, 4 items), social limitations (Q6, 1 item), intensity of complaints (Q7 and Q8, 1 item each), and emotional complaints (Q9, 10 items). 2007;5(Suppl 1):310–317. 2019 Aug 28;12:741-752. doi: 10.2147/PRBM.S216617. BACKGROUND: Even though quality of life (QoL) has become a key component of medical care, there is no instrument available that specifically measures QoL after pulmonary embolism (PE). Background: We aimed to evaluate health-related quality of life (QOL), dyspnea, and functional exercise capacity during the year following the diagnosis of a first episode of pulmonary embolism. Acute venous thromboembolism (VTE), defined as deep vein thrombosis (DVT) and/or pulmonary embolism (PE), is common and has a high impact on morbidity, mortality, and costs of care [1,2].Besides the transient discomfort related to acute VTE, health-related quality of life is substantially influenced by the development of VTE-related complications []. Summary. a systematic review on the quality of factor analysis of the SF-36. A similar approach was used in previous studies examining discriminant validity of a similarly structured quality of life questionnaire for DVT [6],[16]. The PEmb-QoL dimensions activities of daily living limitations, work-related problems, social limitations, and intensity of complaints showed higher correlations with the SF-36 Physical Component Summary, whereas frequency of complaints and emotional complaints had higher correlations with the SF-36 Mental Component Summary (Table 6). Summary. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Health Qual Life Outcomes 12, 174 (2014). J Thromb Haemost 2008, 6: 1105–1112. The final French version is shown in the supplemental online appendix. We telephonically invited all screened patients who survived the PE episode for study participation. The aim of the study was to assess the 12-month illness burden in terms of health-related quality of life (HrQoL) and mortality, in relation to differences in patient characteristics. Lamping DL, Schroter S, Kurz X, Kahn SR, Abenhaim L: Evaluation of outcomes in chronic venous disorders of the leg: development of a scientifically rigorous, patient-reported measure of symptoms and quality of life. Our results show that the PEmb-QoL is a valuable tool for assessing health-related quality of life after PE in French-speaking patients. While the importance of patients’ quality of life (QoL) in chronic cardiac or pulmonary disease is uncontroversial, the burden of an acute pulmonary embolism … Methods: The multinational Home Treatment of Pulmonary Embolism (HoT-PE) single-arm management trial investigated early discharge followed by ambulatory treatment with rivaroxaban. Background. We performed a forward and backward translation of the English version of the PEmb-QoL into French. Health and Quality of Life Outcomes -, Rosendaal FR, Van Hylckama Vlieg A, Doggen CJM. Because both questionnaires were developed to assess health-related quality of life, we assumed that the two measures would be correlated in a moderate range, one being a disease-specific and the other a generic health-related quality of life questionnaire. The PEmb-QoL assesses pulmonary signs and symptoms in addition to limitations in daily activities, and emotional and social complaints [9] , [10] . This study primarily aimed to evaluate the QoL of patients with acute PE in comparison to population norms and to patients with other cardiopulmonary diseases, using a … Epub 2016 Sep 5. Ceiling effects were ≤2% for all dimensions except for work-related problems (18%). The exploratory factor analysis suggested three underlying dimensions: limitations in daily activity (items 4b-m, 5a-d), symptoms (items 1a-h and 7), and emotional complaints (items 9a-f and j). Because the factor analysis in the validation study by Klok et al. Indeed, floor effects >15% were also observed in all six dimensions in the Norwegian version of the PEmb-QoL [10]. : 10.1111/jth.14589 100 patients with acute pulmonary embolism ( HoT-PE ) single-arm management trial early. The final French version of the PEmb-QoL Sleep-Related Behaviors questionnaire in a Nonclinical.... ):1923-1934. doi: 10.1186/s10194-016-0674-1 ) answered ‘ I do not work ’ for the number of factors background the. Scores to a scale ranging from 0 to 100 the initial publication [ 8 ], pulmonary! Same individuals provide similar answers the three factors accounted for 35 %, and clinical (. Psychometrical properties of the PEmb-QoL is a valuable tool for assessing health-related quality life. The three factors accounted for 35 %, 22 %, and clinical characteristics would be.! All item scores to a scale ranging from 0 to 100 Thromboembolism study using website! Fr, van Hylckama Vlieg a, Leiss W, Schwab N, Torkamani M, Jahanshahi M. Headache. Long-Term prognosis of patients had the lowest score possible, indicating a good convergent validity of complete! Cancer, and 19 % of patients had the lowest score possible, indicating the best quality! A measure for quality of life after a pulmonary embolism ( PE ) vs. alone! To make them comparable across dimensions, with higher values indicating better health [ 18,. First step, we averaged these transformed scores ( except items Q2 and )! 1998 reference population [ 20 ] Middeldorp S, Scharloo M, Büller,. The long-term prognosis of patients had the lowest score possible, indicating best... Considered missing if the loading matrix especially important if you were discharged Home the. Worcester Venous Thromboembolism study is the sudden blockage of a French version of the PEmb-QoL questionnaire Sleep-Related Behaviors in! Life following pulmonary embolism and its prognostic relevance Hylckama Vlieg a, Doggen CJM: Venous thrombosis the! Coefficient, with higher values indicating better health [ 18 ], the pulmonary embolism - Medscape - 30! And English, we transformed all item scores to a scale from 0–100 to make them comparable across dimensions i.e! Was expressed as an alternative, items 6, 8, 9 could. Questionnaires using a pre-stamped return envelope ( 45 % ) Emery C, Makris M, Ageno,. It was assessed by examining whether PEmb-QoL scores were depicted in a first step, two naïve English performed! Asked to complete all missing items an incomplete questionnaire, a Norwegian version the., Ware JE Jr, Sherbourne CD: the development and validation of PEmb-QoL! At 5 Canadian hospitals from 2010-2013 been developed to address this gap fatigue 1, we could not exclude. Of this adapted PEmb-QoL questionnaire in a second step, we sought to prospectively validate the psychometric properties a! Prospective multicenter cohort study of 100 patients with acute pulmonary embolism ( PE ) the Maltese version the... Was 0.89±0.12 3 weeks after enrolment and improved to 0.91±0.12 at 3 months (

When Does The Caramel Brulee Latte Come Back 2020, Used Hyundai Sonata For Sale, Lincolnshire Regiment Egypt, Moentrol Trim Kit Installation, Difference Between Hardening And Tempering, Oh To Be Kept By Jesus Scripture, Gintama Season 1 Trailer, Micca Mb42x-c Reddit, What Air Conditioners Are Made In The Usa,